Route 66, a small canvas reading “USA/66," refers to U.S. Route 66, one of the first national highways in the United States and one with multiple personal associations for Indiana, who recounted having spent much of his childhood in an automobile. The first reference to Route 66 in Indiana's work appeared in his pivotal painting The American Dream, I (1960–61), where it is one of four highways named. In 2002, Indiana would return to the subject in the diptych US 66 (States)/US 66 (Cities).
